Assay Detail

CHEMBL4404579

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells incubated for 1 hr and measured after 36 hrs by PR8-NS1 Gaussia luciferase reporter gene assay

ChEMBL ↗

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Target

Influenza A virus (CHEMBL613740) ↗

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Primary target Influenza A virus

CHEMBL613740

Anchored from Assay target.

Protein identity Influenza A virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Influenza A virus
Confidence	1 — Organism
Curated By	Autocuration

Target

Influenza A virus (CHEMBL613740) ↗

Type	ORGANISM
Organism	Influenza A virus

Publication

Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir.

Gaisina IN, Peet NP, Cheng H, Li P, Du R, Cui Q, Furlong K, Manicassamy B, Caffrey M, Thatcher GRJ, Rong L.
J Med Chem (2020) 63 : 3120 -3130
PubMed 32069052 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC30	2	-	-
EC40	2	-	-
EC50	2	6.62	6.73
EC60	2	-	-
EC70	2	-	-
EC80	2	-	-
EC90	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4435674	—	—	7	6.73
CHEMBL674	OSELTAMIVIR CARBOXYLATE	-1.0	7	6.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4435674	—	EC50	=	187.0	nM	6.73
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC50	=	318.0	nM	6.50
CHEMBL4435674	—	EC30	=	134.0	nM	-
CHEMBL4435674	—	EC40	=	160.0	nM	-
CHEMBL4435674	—	EC60	=	219.0	nM	-
CHEMBL4435674	—	EC70	=	260.0	nM	-
CHEMBL4435674	—	EC80	=	321.0	nM	-
CHEMBL4435674	—	EC90	=	439.0	nM	-
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC30	=	160.0	nM	-
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC40	=	229.0	nM	-
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC60	=	441.0	nM	-
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC70	=	629.0	nM	-
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC80	=	972.0	nM	-
CHEMBL674	OSELTAMIVIR CARBOXYLATE	EC90	=	1871.0	nM	-