Assay Detail
Functional
CHEMBL4404580
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Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells incubated for 1 hr and measured after 36 hrs in presence of 156 nM Oseltamivir carboxylate by PR8-NS1 Gaussia luciferase reporter gene assay
7
Total Activities
1
Compounds Tested
7
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC30 | 1 | - | - |
| EC40 | 1 | - | - |
| EC50 | 1 | 7.31 | 7.31 |
| EC60 | 1 | - | - |
| EC70 | 1 | - | - |
| EC80 | 1 | - | - |
| EC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435674 | — | — | 7 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435674 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4435674 | — | EC30 | = | 35.0 | nM | - |
| CHEMBL4435674 | — | EC40 | = | 42.0 | nM | - |
| CHEMBL4435674 | — | EC60 | = | 57.0 | nM | - |
| CHEMBL4435674 | — | EC70 | = | 68.0 | nM | - |
| CHEMBL4435674 | — | EC80 | = | 83.0 | nM | - |
| CHEMBL4435674 | — | EC90 | = | 114.0 | nM | - |