Assay Detail
Binding
CHEMBL4404793
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stabilization of wild type human transthyretin expressed in Escherichia coli BL21(DE3) Star assessed as dissociation constant for TTR-amyloid beta (12 to 28) complex formation at 200 uM at 25 degC pre-incubated with transthyretin before amyloid beta (12 to 28) addition by ITC assay (Rvb = 3 +/- 0.2 microM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.74 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232738 | — | — | 1 | 6.09 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.57 |
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232738 | — | Kd | = | 810.0 | nM | 6.09 |
| CHEMBL898 | DIFLUNISAL | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 2800.0 | nM | 5.55 |