Assay Detail
Binding
CHEMBL4404854
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Inhibition of ATX in mouse plasma after 2 hrs by LC-MS/MS analysis
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 7.26 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4529959 | — | — | 1 | 8.48 |
| CHEMBL4515130 | — | — | 1 | 8.03 |
| CHEMBL4466454 | — | — | 1 | 8.00 |
| CHEMBL4465067 | — | — | 1 | 7.96 |
| CHEMBL4442653 | — | — | 1 | 7.89 |
| CHEMBL4593078 | — | — | 1 | 7.85 |
| CHEMBL4581989 | — | — | 1 | 7.82 |
| CHEMBL4474913 | — | — | 1 | 7.80 |
| CHEMBL4453366 | — | — | 1 | 7.72 |
| CHEMBL4451331 | — | — | 1 | 7.68 |
| CHEMBL4482895 | — | — | 1 | 7.64 |
| CHEMBL4469815 | — | — | 1 | 7.58 |
| CHEMBL4438238 | — | — | 1 | 7.52 |
| CHEMBL4471030 | — | — | 1 | 7.51 |
| CHEMBL4572641 | — | — | 1 | 7.51 |
| CHEMBL4534048 | — | — | 1 | 7.43 |
| CHEMBL4515759 | — | — | 1 | 7.40 |
| CHEMBL4474496 | — | — | 1 | 7.36 |
| CHEMBL4535941 | — | — | 1 | 7.31 |
| CHEMBL4538038 | — | — | 1 | 7.25 |
| CHEMBL4440388 | — | — | 1 | 7.24 |
| CHEMBL4573110 | — | — | 1 | 7.15 |
| CHEMBL4444474 | — | — | 1 | 7.14 |
| CHEMBL4437039 | — | — | 1 | 7.14 |
| CHEMBL4521040 | — | — | 1 | 7.10 |
| CHEMBL4524594 | — | — | 1 | 7.05 |
| CHEMBL4589705 | — | — | 1 | 6.92 |
| CHEMBL4531573 | — | — | 1 | 6.80 |
| CHEMBL4468331 | — | — | 1 | 6.75 |
| CHEMBL4474949 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4529959 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4515130 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4466454 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4465067 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4442653 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4593078 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4581989 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4474913 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4453366 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4451331 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4482895 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4469815 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4438238 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4572641 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4471030 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4534048 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4515759 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4474496 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4535941 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4538038 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4440388 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4573110 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4444474 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4437039 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4521040 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4524594 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4589705 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4531573 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4468331 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4474949 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4545770 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4464013 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4567075 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4456290 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4588157 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4450358 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1511459 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4562354 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3288549 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4471532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4475101 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4472990 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4517964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4563429 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4556613 | — | IC50 | - | — | - | |
| CHEMBL4461454 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4536761 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1382220 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4544786 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4549240 | — | IC50 | > | 50000.0 | nM | - |