Assay Detail
Functional
CHEMBL4404864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.27 | 6.58 |
| pEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4584743 | — | — | 1 | 6.58 |
| CHEMBL4473184 | — | — | 1 | 6.45 |
| CHEMBL4560915 | — | — | 1 | 6.42 |
| CHEMBL4516265 | — | — | 1 | 6.40 |
| CHEMBL4447610 | — | — | 1 | 6.30 |
| CHEMBL4470184 | — | — | 1 | 6.28 |
| CHEMBL4448591 | — | — | 1 | 6.27 |
| CHEMBL4567938 | — | — | 1 | 6.23 |
| CHEMBL4470725 | — | — | 1 | 6.21 |
| CHEMBL4515057 | — | — | 1 | 6.16 |
| CHEMBL4457531 | — | — | 1 | 6.16 |
| CHEMBL4443269 | — | — | 1 | 6.14 |
| CHEMBL4570341 | — | — | 1 | 5.92 |
| CHEMBL4439965 | — | — | 1 | - |
| CHEMBL4590614 | — | — | 1 | - |
| CHEMBL4585373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4584743 | — | EC50 | = | 263.03 | nM | 6.58 |
| CHEMBL4473184 | — | EC50 | = | 354.81 | nM | 6.45 |
| CHEMBL4560915 | — | EC50 | = | 380.19 | nM | 6.42 |
| CHEMBL4516265 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4447610 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4470184 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL4448591 | — | EC50 | = | 537.03 | nM | 6.27 |
| CHEMBL4567938 | — | EC50 | = | 588.84 | nM | 6.23 |
| CHEMBL4470725 | — | EC50 | = | 616.6 | nM | 6.21 |
| CHEMBL4515057 | — | EC50 | = | 691.83 | nM | 6.16 |
| CHEMBL4457531 | — | EC50 | = | 691.83 | nM | 6.16 |
| CHEMBL4443269 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL4570341 | — | EC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL4439965 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL4590614 | — | pEC50 | - | — | - | |
| CHEMBL4585373 | — | pEC50 | - | — | - |