Assay Detail
ADMET
CHEMBL4405034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit based
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 9.23 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4566742 | — | — | 1 | 10.21 |
| CHEMBL4435111 | — | — | 1 | 9.92 |
| CHEMBL4441748 | — | — | 1 | 9.91 |
| CHEMBL4453005 | — | — | 1 | 9.81 |
| CHEMBL4524402 | — | — | 1 | 9.81 |
| CHEMBL4441871 | — | — | 1 | 9.79 |
| CHEMBL4461456 | — | — | 1 | 9.77 |
| CHEMBL4589927 | — | — | 1 | 9.65 |
| CHEMBL4592553 | — | — | 1 | 9.63 |
| CHEMBL4530777 | — | — | 1 | 9.52 |
| CHEMBL4444578 | — | — | 1 | 9.50 |
| CHEMBL4473426 | — | — | 1 | 9.50 |
| CHEMBL4460623 | — | — | 1 | 9.45 |
| CHEMBL4591859 | — | — | 1 | 9.41 |
| CHEMBL4522249 | — | — | 1 | 9.29 |
| CHEMBL4454600 | — | — | 1 | 9.25 |
| CHEMBL4466777 | — | — | 1 | 9.18 |
| CHEMBL4472307 | — | — | 1 | 9.17 |
| CHEMBL4461705 | — | — | 1 | 9.17 |
| CHEMBL4465097 | — | — | 1 | 9.07 |
| CHEMBL4452707 | — | — | 1 | 9.06 |
| CHEMBL4461658 | — | — | 1 | 8.93 |
| CHEMBL4533993 | — | — | 1 | 8.79 |
| CHEMBL4575003 | — | — | 1 | 8.61 |
| CHEMBL4472329 | — | — | 1 | 8.61 |
| CHEMBL4466905 | — | — | 1 | 8.59 |
| CHEMBL4462322 | — | — | 1 | 7.52 |
| CHEMBL4451207 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4566742 | — | Ki | = | 0.06166 | nM | 10.21 |
| CHEMBL4435111 | — | Ki | = | 0.1202 | nM | 9.92 |
| CHEMBL4441748 | — | Ki | = | 0.123 | nM | 9.91 |
| CHEMBL4453005 | — | Ki | = | 0.1549 | nM | 9.81 |
| CHEMBL4524402 | — | Ki | = | 0.1549 | nM | 9.81 |
| CHEMBL4441871 | — | Ki | = | 0.1622 | nM | 9.79 |
| CHEMBL4461456 | — | Ki | = | 0.1698 | nM | 9.77 |
| CHEMBL4589927 | — | Ki | = | 0.2239 | nM | 9.65 |
| CHEMBL4592553 | — | Ki | = | 0.2344 | nM | 9.63 |
| CHEMBL4530777 | — | Ki | = | 0.302 | nM | 9.52 |
| CHEMBL4444578 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL4473426 | — | Ki | = | 0.3162 | nM | 9.50 |
| CHEMBL4460623 | — | Ki | = | 0.3548 | nM | 9.45 |
| CHEMBL4591859 | — | Ki | = | 0.389 | nM | 9.41 |
| CHEMBL4522249 | — | Ki | = | 0.5129 | nM | 9.29 |
| CHEMBL4454600 | — | Ki | = | 0.5623 | nM | 9.25 |
| CHEMBL4466777 | — | Ki | = | 0.6607 | nM | 9.18 |
| CHEMBL4472307 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL4461705 | — | Ki | = | 0.6761 | nM | 9.17 |
| CHEMBL4465097 | — | Ki | = | 0.8511 | nM | 9.07 |
| CHEMBL4452707 | — | Ki | = | 0.871 | nM | 9.06 |
| CHEMBL4461658 | — | Ki | = | 1.175 | nM | 8.93 |
| CHEMBL4533993 | — | Ki | = | 1.622 | nM | 8.79 |
| CHEMBL4575003 | — | Ki | = | 2.455 | nM | 8.61 |
| CHEMBL4472329 | — | Ki | = | 2.455 | nM | 8.61 |
| CHEMBL4466905 | — | Ki | = | 2.57 | nM | 8.59 |
| CHEMBL4462322 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL4451207 | — | Ki | = | 63.1 | nM | 7.20 |