Assay Detail
Binding
CHEMBL4406714
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Inhibition of HIV-1 protease
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 10.50 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.80 |
| CHEMBL4533315 | — | — | 1 | 10.62 |
| CHEMBL4437746 | — | — | 1 | 10.57 |
| CHEMBL4469549 | — | — | 1 | 10.47 |
| CHEMBL4460799 | — | — | 1 | 10.44 |
| CHEMBL4568050 | — | — | 1 | 10.33 |
| CHEMBL4592624 | — | — | 1 | 10.27 |
| CHEMBL4514504 | — | — | 1 | - |
| CHEMBL4545005 | — | — | 1 | - |
| CHEMBL4435411 | — | — | 1 | - |
| CHEMBL4586218 | — | — | 1 | - |
| CHEMBL4449179 | — | — | 1 | - |
| CHEMBL4532946 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.016 | nM | 10.80 |
| CHEMBL4533315 | — | Ki | = | 0.024 | nM | 10.62 |
| CHEMBL4437746 | — | Ki | = | 0.027 | nM | 10.57 |
| CHEMBL4469549 | — | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL4460799 | — | Ki | = | 0.036 | nM | 10.44 |
| CHEMBL4568050 | — | Ki | = | 0.047 | nM | 10.33 |
| CHEMBL4592624 | — | Ki | = | 0.054 | nM | 10.27 |
| CHEMBL4514504 | — | Ki | = | 0.002 | nM | - |
| CHEMBL4545005 | — | Ki | = | 0.008 | nM | - |
| CHEMBL4435411 | — | Ki | = | 0.006 | nM | - |
| CHEMBL4586218 | — | Ki | = | 0.007 | nM | - |
| CHEMBL4449179 | — | Ki | = | 0.008 | nM | - |
| CHEMBL4532946 | — | Ki | = | 0.002 | nM | - |