Assay Detail

CHEMBL4407035

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Functional

Cytotoxicity against human PC3 cells after 72 hrs by CellTiter one aqueous solution assay

ChEMBL ↗

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Target

PC-3 (CHEMBL390) ↗

Open DB target context

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PC-3 (CHEMBL390) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target PC-3

CHEMBL390

Anchored from Assay target.

Protein identity PC-3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-3
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-3 (CHEMBL390) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Anti-cancer effects of cinnamon: Insights into its apoptosis effects.

Sadeghi S, Davoodvandi A, Pourhanifeh MH, Sharifi N, ArefNezhad R, Sahebnasagh R, Moghadam SA, Sahebkar A, Mirzaei H.
Eur J Med Chem (2019) 178 : 131 -140
PubMed 31195168 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.00	6.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL42710	EUGENOL	0.5	1	6.00
CHEMBL299613	2-METHOXYESTRADIOL	2.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL42710	EUGENOL	IC50	=	1000.0	nM	6.00
CHEMBL299613	2-METHOXYESTRADIOL	IC50	=	82.0	ug.mL-1	-