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Assay Detail

CHEMBL4407040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of P300 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone acetyltransferase p300 (CHEMBL3784)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism.
Huang M, Huang J, Zheng Y, Sun Q.
Eur J Med Chem (2019) 178 : 259 -286
PubMed 31195169 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.20 6.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4579084 1 6.12
CHEMBL4446385 1 5.47
CHEMBL235195 TAXODIONE 1 5.31
CHEMBL4456463 1 5.30
CHEMBL4446656 1 5.30
CHEMBL4516760 1 5.30
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 4.52
CHEMBL4515219 1 4.24
CHEMBL4468817 1 -
CHEMBL3775671 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4579084 IC50 = 750.0 nM 6.12
CHEMBL4446385 IC50 = 3400.0 nM 5.47
CHEMBL235195 TAXODIONE IC50 = 4850.0 nM 5.31
CHEMBL4456463 IC50 = 5000.0 nM 5.30
CHEMBL4446656 IC50 = 5000.0 nM 5.30
CHEMBL4516760 IC50 = 5000.0 nM 5.30
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 30000.0 nM 4.52
CHEMBL4515219 IC50 = 57500.0 nM 4.24
CHEMBL4468817 IC50 > 2000.0 nM -
CHEMBL3775671 IC50 > 30000.0 nM -