Assay Detail
Binding
CHEMBL4407210
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Inhibition of recombinant ovine COX2 using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 2 mins by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Human disorders associated with inflammation and the evolving role of natural products to overcome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.72 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473793 | — | — | 1 | 5.03 |
| CHEMBL444478 | ACETOSIDE | 2.0 | 1 | 4.95 |
| CHEMBL4530118 | — | — | 1 | 4.80 |
| CHEMBL4467432 | — | — | 1 | 4.74 |
| CHEMBL4452548 | — | — | 1 | 4.71 |
| CHEMBL4455571 | — | — | 1 | 4.67 |
| CHEMBL4465765 | — | — | 1 | 4.61 |
| CHEMBL4556386 | — | — | 1 | 4.54 |
| CHEMBL4576547 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473793 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL444478 | ACETOSIDE | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4530118 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4467432 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4452548 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4455571 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL4465765 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4556386 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL4576547 | — | IC50 | = | 36000.0 | nM | 4.44 |