Assay Detail
Binding
CHEMBL4407299
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Binding affinity to Mycobacterium abscessus N-terminal His-tagged 3C protease linked full length tRNA (m1-G37) methyltransferase expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacteroides abscessus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of Inhibitors against <i>Mycobacterium abscessus</i> tRNA (m<sup>1</sup>G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 49 | 4.96 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4576907 | — | — | 1 | 6.92 |
| CHEMBL4583591 | — | — | 1 | 6.75 |
| CHEMBL4585013 | — | — | 1 | 6.44 |
| CHEMBL4454013 | — | — | 1 | 6.30 |
| CHEMBL4551843 | — | — | 1 | 6.23 |
| CHEMBL4435815 | — | — | 1 | 5.89 |
| CHEMBL4471268 | — | — | 1 | 5.50 |
| CHEMBL4519568 | — | — | 1 | 5.34 |
| CHEMBL4548872 | — | — | 1 | 5.30 |
| CHEMBL4447182 | — | — | 1 | 5.17 |
| CHEMBL4434680 | — | — | 1 | 5.07 |
| CHEMBL4541236 | — | — | 1 | 5.00 |
| CHEMBL4517357 | — | — | 1 | 5.00 |
| CHEMBL4446084 | — | — | 1 | 4.96 |
| CHEMBL4572807 | — | — | 1 | 4.92 |
| CHEMBL4531919 | — | — | 1 | 4.92 |
| CHEMBL4461645 | — | — | 1 | 4.92 |
| CHEMBL4571359 | — | — | 1 | 4.89 |
| CHEMBL4583556 | — | — | 1 | 4.85 |
| CHEMBL4537315 | — | — | 1 | 4.72 |
| CHEMBL4537643 | — | — | 1 | 4.57 |
| CHEMBL4526104 | — | — | 1 | 4.52 |
| CHEMBL4536428 | — | — | 1 | 4.48 |
| CHEMBL4474548 | — | — | 1 | 4.23 |
| CHEMBL4453792 | — | — | 1 | 4.16 |
| CHEMBL4457380 | — | — | 1 | 4.14 |
| CHEMBL4461273 | — | — | 1 | 4.05 |
| CHEMBL4449229 | — | — | 1 | 4.04 |
| CHEMBL4567409 | — | — | 1 | 4.00 |
| CHEMBL4475938 | — | — | 1 | 3.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4576907 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL4583591 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL4585013 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL4454013 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4551843 | — | Kd | = | 590.0 | nM | 6.23 |
| CHEMBL4435815 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL4471268 | — | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL4519568 | — | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL4548872 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL4447182 | — | Kd | = | 6700.0 | nM | 5.17 |
| CHEMBL4434680 | — | Kd | = | 8500.0 | nM | 5.07 |
| CHEMBL4541236 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL4517357 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL4446084 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL4461645 | — | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL4572807 | — | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL4531919 | — | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL4571359 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL4583556 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL4537315 | — | Kd | = | 19000.0 | nM | 4.72 |
| CHEMBL4537643 | — | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL4526104 | — | Kd | = | 30000.0 | nM | 4.52 |
| CHEMBL4536428 | — | Kd | = | 33000.0 | nM | 4.48 |
| CHEMBL4474548 | — | Kd | = | 59000.0 | nM | 4.23 |
| CHEMBL4453792 | — | Kd | = | 70000.0 | nM | 4.16 |
| CHEMBL4457380 | — | Kd | = | 73000.0 | nM | 4.14 |
| CHEMBL4461273 | — | Kd | = | 89000.0 | nM | 4.05 |
| CHEMBL4449229 | — | Kd | = | 92000.0 | nM | 4.04 |
| CHEMBL4567409 | — | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL4475938 | — | Kd | = | 110000.0 | nM | 3.96 |
| CHEMBL3751985 | — | Kd | = | 170000.0 | nM | 3.77 |
| CHEMBL4071778 | — | Kd | = | 260000.0 | nM | 3.58 |
| CHEMBL4532147 | — | Kd | - | — | - | |
| CHEMBL4525649 | — | Kd | - | — | - | |
| CHEMBL4440886 | — | Kd | - | — | - | |
| CHEMBL4533375 | — | Kd | - | — | - | |
| CHEMBL4446155 | — | Kd | - | — | - | |
| CHEMBL1650269 | — | Kd | - | — | - | |
| CHEMBL1483289 | — | Kd | - | — | - | |
| CHEMBL4454136 | — | Kd | - | — | - | |
| CHEMBL1229732 | — | Kd | - | — | - | |
| CHEMBL342460 | — | Kd | - | — | - | |
| CHEMBL4550520 | — | Kd | - | — | - | |
| CHEMBL4534988 | — | Kd | - | — | - | |
| CHEMBL4564248 | — | Kd | - | — | - | |
| CHEMBL4536748 | — | Kd | = | 490000.0 | nM | - |
| CHEMBL4466923 | — | Kd | = | 2000000.0 | nM | - |
| CHEMBL4434796 | — | Kd | = | 190000.0 | nM | - |
| CHEMBL4459768 | — | Kd | = | 710000.0 | nM | - |