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Assay Detail

CHEMBL4407341

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Functional
Antiproliferative activity against human OVCAR8 cells
ChEMBL ↗
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type OVCAR-8
Confidence 1 — Organism
Curated By Autocuration

Target

OVCAR-8 (CHEMBL612555) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.
Dong X, Zhan W, Zhao M, Che J, Dai X, Wu Y, Xu L, Zhou Y, Zhao Y, Tian T, Cheng G, Jin Z, Li J, Shao Y, He Q, Yang B, Weng Q, Hu Y.
J Med Chem (2019) 62 : 7264 -7288
PubMed 31298542 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 67 5.66 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4457064 — — 1 7.40
CHEMBL4445510 — — 1 6.96
CHEMBL4585120 — — 1 6.92
CHEMBL4591854 — — 1 6.92
CHEMBL3137336 UPROSERTIB 2.0 1 6.62
CHEMBL4441825 — — 1 6.34
CHEMBL4533641 — — 1 6.31
CHEMBL4589576 — — 1 6.24
CHEMBL4451765 — — 1 6.22
CHEMBL4447158 — — 1 6.21
CHEMBL4517950 — — 1 6.21
CHEMBL4567295 — — 1 6.16
CHEMBL4440965 — — 1 6.10
CHEMBL4460525 — — 1 6.06
CHEMBL4435138 — — 1 6.05
CHEMBL4438877 — — 1 6.00
CHEMBL4449509 — — 1 6.00
CHEMBL4568343 — — 1 5.97
CHEMBL4475923 — — 1 5.95
CHEMBL4453662 — — 1 5.94
CHEMBL4554683 — — 1 5.88
CHEMBL4529738 — — 1 5.85
CHEMBL4554668 — — 1 5.84
CHEMBL4590906 — — 1 5.82
CHEMBL4441416 — — 1 5.82
CHEMBL4519793 — — 1 5.81
CHEMBL4470606 — — 1 5.79
CHEMBL4467439 — — 1 5.79
CHEMBL4524940 — — 1 5.78
CHEMBL4450403 — — 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4457064 — IC50 = 40.0 nM 7.40
CHEMBL4445510 — IC50 = 110.0 nM 6.96
CHEMBL4591854 — IC50 = 120.0 nM 6.92
CHEMBL4585120 — IC50 = 120.0 nM 6.92
CHEMBL3137336 UPROSERTIB IC50 = 240.0 nM 6.62
CHEMBL4441825 — IC50 = 460.0 nM 6.34
CHEMBL4533641 — IC50 = 490.0 nM 6.31
CHEMBL4589576 — IC50 = 580.0 nM 6.24
CHEMBL4451765 — IC50 = 600.0 nM 6.22
CHEMBL4447158 — IC50 = 610.0 nM 6.21
CHEMBL4517950 — IC50 = 610.0 nM 6.21
CHEMBL4567295 — IC50 = 690.0 nM 6.16
CHEMBL4440965 — IC50 = 800.0 nM 6.10
CHEMBL4460525 — IC50 = 880.0 nM 6.06
CHEMBL4435138 — IC50 = 900.0 nM 6.05
CHEMBL4438877 — IC50 = 1000.0 nM 6.00
CHEMBL4449509 — IC50 = 990.0 nM 6.00
CHEMBL4568343 — IC50 = 1060.0 nM 5.97
CHEMBL4475923 — IC50 = 1130.0 nM 5.95
CHEMBL4453662 — IC50 = 1150.0 nM 5.94
CHEMBL4554683 — IC50 = 1320.0 nM 5.88
CHEMBL4529738 — IC50 = 1400.0 nM 5.85
CHEMBL4554668 — IC50 = 1450.0 nM 5.84
CHEMBL4590906 — IC50 = 1510.0 nM 5.82
CHEMBL4441416 — IC50 = 1530.0 nM 5.82
CHEMBL4519793 — IC50 = 1560.0 nM 5.81
CHEMBL4467439 — IC50 = 1620.0 nM 5.79
CHEMBL4470606 — IC50 = 1610.0 nM 5.79
CHEMBL4524940 — IC50 = 1660.0 nM 5.78
CHEMBL4450403 — IC50 = 1760.0 nM 5.75
CHEMBL4546392 — IC50 = 1840.0 nM 5.74
CHEMBL4544069 — IC50 = 1920.0 nM 5.72
CHEMBL4528834 — IC50 = 2110.0 nM 5.68
CHEMBL4574492 — IC50 = 2180.0 nM 5.66
CHEMBL4543839 — IC50 = 2510.0 nM 5.60
CHEMBL4445690 — IC50 = 2900.0 nM 5.54
CHEMBL4588742 — IC50 = 3030.0 nM 5.52
CHEMBL4582476 — IC50 = 3510.0 nM 5.46
CHEMBL4518386 — IC50 = 3500.0 nM 5.46
CHEMBL4470602 — IC50 = 3460.0 nM 5.46
CHEMBL4578995 — IC50 = 3680.0 nM 5.43
CHEMBL4450141 — IC50 = 4280.0 nM 5.37
CHEMBL4531682 — IC50 = 4410.0 nM 5.36
CHEMBL4439720 — IC50 = 4540.0 nM 5.34
CHEMBL4560290 — IC50 = 4920.0 nM 5.31
CHEMBL4531735 — IC50 = 4960.0 nM 5.30
CHEMBL4540052 — IC50 = 5000.0 nM 5.30
CHEMBL4447967 — IC50 = 5120.0 nM 5.29
CHEMBL4460756 — IC50 = 5330.0 nM 5.27
CHEMBL4593509 — IC50 = 5820.0 nM 5.24