Assay Detail
Binding
CHEMBL4407365
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt3 (unknown origin) by mobile shift assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-gamma serine/threonine-protein kinase (CHEMBL4816) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.40 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457064 | — | — | 1 | 10.00 |
| CHEMBL4441825 | — | — | 1 | 9.92 |
| CHEMBL3137336 | UPROSERTIB | 2.0 | 1 | 8.89 |
| CHEMBL4440965 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457064 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4441825 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL3137336 | UPROSERTIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4440965 | — | IC50 | = | 1.7 | nM | 8.77 |