Assay Detail
Binding
CHEMBL4407367
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Inhibition of PKC (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441825 | — | — | 1 | 7.80 |
| CHEMBL4440965 | — | — | 1 | 7.03 |
| CHEMBL4457064 | — | — | 1 | 6.81 |
| CHEMBL3137336 | UPROSERTIB | 2.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441825 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4440965 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4457064 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL3137336 | UPROSERTIB | IC50 | = | 753.0 | nM | 6.12 |