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Assay Detail

CHEMBL4407641

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human PBMC
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type PBMC
Confidence 1 — Organism
Curated By Autocuration

Target

PBMC (CHEMBL613107)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.
da Silva Júnior EN, Jardim GAM, Jacob C, Dhawa U, Ackermann L, de Castro SL.
Eur J Med Chem (2019) 179 : 863 -915
PubMed 31306817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.33 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3114588 1 7.16
CHEMBL4525662 1 5.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3114588 IC50 = 70.0 nM 7.16
CHEMBL4525662 IC50 = 3260.0 nM 5.49