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Assay Detail

CHEMBL4407756

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-d-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by spectrophotometric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Alpha glucosidase (CHEMBL3833502)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Role of sulphur-heterocycles in medicinal chemistry: An update.
Pathania S, Narang RK, Rawal RK.
Eur J Med Chem (2019) 180 : 486 -508
PubMed 31330449 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.54 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4453256 1 5.54
CHEMBL404271 ACARBOSE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4453256 IC50 = 2850.0 nM 5.54
CHEMBL404271 ACARBOSE IC50 = 817380.0 nM -