Assay Detail
Binding
CHEMBL4407817
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Escherichia coli IspC expressed in Escherichia coli M15 using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL3421521) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
Publication
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.81 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4567904 | — | — | 1 | 7.89 |
| CHEMBL4590343 | — | — | 1 | 7.75 |
| CHEMBL4474216 | — | — | 1 | 7.66 |
| CHEMBL4592986 | — | — | 1 | 6.80 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | — | 1 | 6.66 |
| CHEMBL4447571 | — | — | 1 | 6.54 |
| CHEMBL4544750 | — | — | 1 | 6.17 |
| CHEMBL4462089 | — | — | 1 | 5.37 |
| CHEMBL4437978 | — | — | 1 | 5.35 |
| CHEMBL4564404 | — | — | 1 | 4.96 |
| CHEMBL4572338 | — | — | 1 | 4.82 |
| CHEMBL4452553 | — | — | 1 | 4.44 |
| CHEMBL4545211 | — | — | 1 | 4.44 |
| CHEMBL4578312 | — | — | 1 | 4.19 |
| CHEMBL4458458 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4567904 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4590343 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4474216 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4592986 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2164257 | FOSMIDOMYCIN SODIUM | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4447571 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4544750 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4462089 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4437978 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4564404 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4572338 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4452553 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4545211 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4578312 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL4458458 | — | IC50 | = | 80000.0 | nM | 4.10 |