Assay Detail
Functional
CHEMBL4408280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.71 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447541 | — | — | 1 | 10.22 |
| CHEMBL4451991 | — | — | 1 | 9.70 |
| CHEMBL4473254 | — | — | 1 | 9.52 |
| CHEMBL4440494 | — | — | 1 | 9.10 |
| CHEMBL4464909 | — | — | 1 | 8.38 |
| CHEMBL4449830 | — | — | 1 | 8.27 |
| CHEMBL4526719 | — | — | 1 | 8.13 |
| CHEMBL4436465 | — | — | 1 | 8.09 |
| CHEMBL4524533 | — | — | 1 | 7.98 |
| CHEMBL4522990 | — | — | 1 | 7.80 |
| CHEMBL4442113 | — | — | 1 | 7.55 |
| CHEMBL4554434 | — | — | 1 | 7.43 |
| CHEMBL4525021 | — | — | 1 | 7.38 |
| CHEMBL4541938 | — | — | 1 | 7.35 |
| CHEMBL4533893 | — | — | 1 | 7.29 |
| CHEMBL4569888 | — | — | 1 | 7.17 |
| CHEMBL4459196 | — | — | 1 | 7.17 |
| CHEMBL4551856 | — | — | 1 | 7.17 |
| CHEMBL4521561 | — | — | 1 | 6.50 |
| CHEMBL4537302 | — | — | 1 | 6.27 |
| CHEMBL4546434 | — | — | 1 | 5.62 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.51 |
| CHEMBL4453762 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447541 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4451991 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4473254 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4440494 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4464909 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4449830 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4526719 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4436465 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4524533 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4522990 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL4442113 | — | IC50 | = | 28.2 | nM | 7.55 |
| CHEMBL4554434 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL4525021 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL4541938 | — | IC50 | = | 44.4 | nM | 7.35 |
| CHEMBL4533893 | — | IC50 | = | 51.3 | nM | 7.29 |
| CHEMBL4569888 | — | IC50 | = | 67.4 | nM | 7.17 |
| CHEMBL4459196 | — | IC50 | = | 68.4 | nM | 7.17 |
| CHEMBL4551856 | — | IC50 | = | 67.4 | nM | 7.17 |
| CHEMBL4521561 | — | IC50 | = | 316.1 | nM | 6.50 |
| CHEMBL4537302 | — | IC50 | = | 540.9 | nM | 6.27 |
| CHEMBL4546434 | — | IC50 | = | 2416.0 | nM | 5.62 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4453762 | — | IC50 | > | 10000.0 | nM | - |