Assay Detail
Functional
CHEMBL4408284
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Antiproliferative activity against human SEM cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.98 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447541 | — | — | 1 | 10.22 |
| CHEMBL4473254 | — | — | 1 | 9.70 |
| CHEMBL4440494 | — | — | 1 | 9.40 |
| CHEMBL4526719 | — | — | 1 | 9.30 |
| CHEMBL4524533 | — | — | 1 | 9.00 |
| CHEMBL4464909 | — | — | 1 | 8.85 |
| CHEMBL4451991 | — | — | 1 | 8.62 |
| CHEMBL4442113 | — | — | 1 | 8.59 |
| CHEMBL4522990 | — | — | 1 | 8.57 |
| CHEMBL4436465 | — | — | 1 | 8.48 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.29 |
| CHEMBL4449830 | — | — | 1 | 7.86 |
| CHEMBL4541938 | — | — | 1 | 7.83 |
| CHEMBL4554434 | — | — | 1 | 7.76 |
| CHEMBL4525021 | — | — | 1 | 7.73 |
| CHEMBL4551856 | — | — | 1 | 7.63 |
| CHEMBL4459196 | — | — | 1 | 7.54 |
| CHEMBL4533893 | — | — | 1 | 7.52 |
| CHEMBL4569888 | — | — | 1 | 6.73 |
| CHEMBL4521561 | — | — | 1 | 6.51 |
| CHEMBL4537302 | — | — | 1 | 6.39 |
| CHEMBL4546434 | — | — | 1 | 5.61 |
| CHEMBL4453762 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447541 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL4473254 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4440494 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4526719 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4524533 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4464909 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4451991 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4442113 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4522990 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4436465 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4449830 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4541938 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL4554434 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL4525021 | — | IC50 | = | 18.7 | nM | 7.73 |
| CHEMBL4551856 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4459196 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL4533893 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL4569888 | — | IC50 | = | 187.2 | nM | 6.73 |
| CHEMBL4521561 | — | IC50 | = | 305.3 | nM | 6.51 |
| CHEMBL4537302 | — | IC50 | = | 406.1 | nM | 6.39 |
| CHEMBL4546434 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4453762 | — | IC50 | = | 3340.0 | nM | 5.48 |