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Assay Detail

CHEMBL4408337

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Mycobacterium tuberculosis ICL expressed in Escherichia coli BL21 (DE3) cells using DL-isocitric acid trisodium salt hydrate as substrate after 30 mins
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mycobacterium tuberculosis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Isocitrate lyase (CHEMBL1667699)
Type SINGLE PROTEIN
Organism Mycobacterium tuberculosis

Publication

Phenolic N-monosubstituted carbamates: Antitubercular and toxicity evaluation of multi-targeting compounds.
Krátký M, Janďourek O, Baranyai Z, Novotná E, Stolaříková J, Bősze S, Vinšová J.
Eur J Med Chem (2019) 181 : 111578 -111578
PubMed 31401536 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.51 4.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4226192 1 4.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4226192 IC50 = 30900.0 nM 4.51