Assay Detail
Functional
CHEMBL4408364
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Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.96 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4483313 | — | — | 1 | 5.72 |
| CHEMBL4586740 | — | — | 1 | 5.11 |
| CHEMBL4471187 | — | — | 1 | 5.08 |
| CHEMBL4580198 | — | — | 1 | 5.08 |
| CHEMBL4558237 | — | — | 1 | 5.00 |
| CHEMBL1650637 | — | — | 1 | 4.75 |
| CHEMBL4574404 | — | — | 1 | 4.66 |
| CHEMBL311932 | — | — | 1 | 4.28 |
| CHEMBL4469402 | — | — | 1 | - |
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4483313 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4586740 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4471187 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4580198 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4558237 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1650637 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4574404 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL311932 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4469402 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL75094 | PRINOMASTAT | IC50 | > | 500000.0 | nM | - |