Assay Detail
Binding
CHEMBL4408522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured for 1 min by DTNB reagent-based spectrophotometric analysis
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.35 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165327 | — | — | 1 | 9.44 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.66 |
| CHEMBL3910142 | — | — | 1 | 7.54 |
| CHEMBL4536953 | — | — | 1 | 7.28 |
| CHEMBL4462677 | — | — | 1 | 7.14 |
| CHEMBL4522175 | — | — | 1 | 6.96 |
| CHEMBL4442490 | — | — | 1 | 6.79 |
| CHEMBL4450353 | — | — | 1 | 6.64 |
| CHEMBL4474948 | — | — | 1 | 6.62 |
| CHEMBL4472865 | — | — | 1 | 6.56 |
| CHEMBL4569192 | — | — | 1 | 6.49 |
| CHEMBL4435341 | — | — | 1 | 6.47 |
| CHEMBL4473288 | — | — | 1 | 6.42 |
| CHEMBL4518306 | — | — | 1 | 6.41 |
| CHEMBL4588952 | — | — | 1 | 6.35 |
| CHEMBL4557653 | — | — | 1 | 6.28 |
| CHEMBL4439615 | — | — | 1 | 6.26 |
| CHEMBL4545023 | — | — | 1 | 6.25 |
| CHEMBL4574930 | — | — | 1 | 6.25 |
| CHEMBL4453853 | — | — | 1 | 6.21 |
| CHEMBL4442752 | — | — | 1 | 6.13 |
| CHEMBL4476086 | — | — | 1 | 6.13 |
| CHEMBL4589809 | — | — | 1 | 6.10 |
| CHEMBL4566824 | — | — | 1 | 6.09 |
| CHEMBL4451956 | — | — | 1 | 6.04 |
| CHEMBL4457720 | — | — | 1 | 6.03 |
| CHEMBL4515408 | — | — | 1 | 6.03 |
| CHEMBL4575964 | — | — | 1 | 5.98 |
| CHEMBL4474675 | — | — | 1 | 5.84 |
| CHEMBL4565910 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165327 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3910142 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4536953 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4462677 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4522175 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4442490 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4450353 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL4474948 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL4472865 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL4569192 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4435341 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL4473288 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL4518306 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL4588952 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL4557653 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL4439615 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4574930 | — | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL4545023 | — | IC50 | = | 559.0 | nM | 6.25 |
| CHEMBL4453853 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL4442752 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL4476086 | — | IC50 | = | 747.0 | nM | 6.13 |
| CHEMBL4589809 | — | IC50 | = | 801.0 | nM | 6.10 |
| CHEMBL4566824 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL4451956 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL4457720 | — | IC50 | = | 943.0 | nM | 6.03 |
| CHEMBL4515408 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL4575964 | — | IC50 | = | 1055.0 | nM | 5.98 |
| CHEMBL4474675 | — | IC50 | = | 1445.0 | nM | 5.84 |
| CHEMBL4565910 | — | IC50 | = | 1959.0 | nM | 5.71 |
| CHEMBL4439886 | — | IC50 | = | 2097.0 | nM | 5.68 |
| CHEMBL4437417 | — | IC50 | = | 2093.0 | nM | 5.68 |
| CHEMBL4529285 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL4450342 | — | IC50 | = | 4176.0 | nM | 5.38 |
| CHEMBL4463270 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL4558783 | — | IC50 | = | 7031.0 | nM | 5.15 |