Assay Detail
Binding
CHEMBL4408554
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Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate incubated for 48 hrs
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.44 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.00 |
| CHEMBL4514196 | — | — | 1 | 8.00 |
| CHEMBL4552649 | — | — | 1 | 7.98 |
| CHEMBL4457875 | — | — | 1 | 7.84 |
| CHEMBL4581189 | — | — | 1 | 7.84 |
| CHEMBL4552082 | — | — | 1 | 7.77 |
| CHEMBL4447280 | — | — | 1 | 7.75 |
| CHEMBL4436582 | — | — | 1 | 7.72 |
| CHEMBL4444787 | — | — | 1 | 7.72 |
| CHEMBL4455785 | — | — | 1 | 7.68 |
| CHEMBL4472697 | — | — | 1 | 7.68 |
| CHEMBL4473190 | — | — | 1 | 7.64 |
| CHEMBL4455008 | — | — | 1 | 7.62 |
| CHEMBL4454093 | — | — | 1 | 7.62 |
| CHEMBL4514159 | — | — | 1 | 7.60 |
| CHEMBL4567170 | — | — | 1 | 7.58 |
| CHEMBL4464324 | — | — | 1 | 7.46 |
| CHEMBL4456809 | — | — | 1 | 7.44 |
| CHEMBL4440145 | — | — | 1 | 7.43 |
| CHEMBL4462873 | — | — | 1 | 7.36 |
| CHEMBL4463815 | — | — | 1 | 7.03 |
| CHEMBL4460529 | — | — | 1 | 6.98 |
| CHEMBL4455935 | — | — | 1 | 6.92 |
| CHEMBL4439914 | — | — | 1 | 6.90 |
| CHEMBL4441056 | — | — | 1 | 6.88 |
| CHEMBL4565478 | — | — | 1 | 6.84 |
| CHEMBL4464199 | — | — | 1 | 6.83 |
| CHEMBL4519220 | — | — | 1 | 6.07 |
| CHEMBL4556184 | — | — | 1 | - |
| CHEMBL4531273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4514196 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL4552649 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4457875 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4581189 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL4552082 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL4447280 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL4436582 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL4444787 | — | IC50 | = | 19.1 | nM | 7.72 |
| CHEMBL4455785 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4472697 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4473190 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4455008 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4454093 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4514159 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4567170 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4464324 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4456809 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4440145 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL4462873 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4463815 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4460529 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4455935 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4439914 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4441056 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4565478 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4464199 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4519220 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4556184 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4531273 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4469573 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4540060 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4543296 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL4573286 | — | IC50 | > | 200.0 | nM | - |