Assay Detail
Binding
CHEMBL4408555
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Inhibition of recombinant N-terminal His-tagged human IDO1 expressed in Escherichia coli assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.97 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL4472697 | — | — | 1 | 7.11 |
| CHEMBL4454093 | — | — | 1 | 7.00 |
| CHEMBL4455008 | — | — | 1 | 7.00 |
| CHEMBL4552082 | — | — | 1 | 6.99 |
| CHEMBL4514196 | — | — | 1 | 6.98 |
| CHEMBL4581189 | — | — | 1 | 6.96 |
| CHEMBL4567170 | — | — | 1 | 6.94 |
| CHEMBL4552649 | — | — | 1 | 6.94 |
| CHEMBL4436582 | — | — | 1 | 6.92 |
| CHEMBL4514159 | — | — | 1 | 6.92 |
| CHEMBL4444787 | — | — | 1 | 6.92 |
| CHEMBL4455785 | — | — | 1 | 6.92 |
| CHEMBL4460529 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4472697 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4454093 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4455008 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4552082 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4514196 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4581189 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4567170 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4552649 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4436582 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4514159 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4444787 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4455785 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL4460529 | — | IC50 | = | 130.0 | nM | 6.89 |