Assay Detail
Binding
CHEMBL4408783
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Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.90 | 8.40 |
| IC50 | 1 | 5.92 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436535 | — | — | 1 | 8.40 |
| CHEMBL3603847 | — | — | 1 | 8.00 |
| CHEMBL4582951 | — | — | 1 | 7.89 |
| CHEMBL4441405 | — | — | 1 | 7.32 |
| CHEMBL4468670 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436535 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3603847 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4582951 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4441405 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4468670 | — | IC50 | = | 1200.0 | nM | 5.92 |