Assay Detail
Binding
CHEMBL4408802
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Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) using 5-FAM YSPTSPSYSPTSPSYSPTSPSKKKK as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.13 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4582951 | — | — | 1 | 7.76 |
| CHEMBL4436535 | — | — | 1 | 7.20 |
| CHEMBL4441405 | — | — | 1 | 6.98 |
| CHEMBL3603847 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4582951 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL4436535 | — | Ki | = | 62.5 | nM | 7.20 |
| CHEMBL4441405 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL3603847 | — | Ki | = | 255.0 | nM | 6.59 |