Assay Detail
Binding
CHEMBL4408808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CDK4/cyclinD1
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | - | - |
| IC50 | 1 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3894860 | TRILACICLIB | 4.0 | 2 | 9.00 |
| CHEMBL3904602 | LEROCICLIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3894860 | TRILACICLIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3904602 | LEROCICLIB | EC50 | < | 100.0 | nM | - |
| CHEMBL3894860 | TRILACICLIB | EC50 | < | 100.0 | nM | - |