Assay Detail
Functional
CHEMBL4409205
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity against H2O2-induced cell damage in human HBMEC2 cells assessed as increase in cell viability preincubated for 24 hrs followed by H2O2 addition and measured after 4 hrs by MTT assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HBMEC-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of cinnamic acid derivatives with synergetic neuroprotection and angiogenesis effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 45 | 5.05 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471581 | — | — | 1 | 5.59 |
| CHEMBL4437828 | — | — | 1 | 5.49 |
| CHEMBL4589583 | — | — | 1 | 5.45 |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | 5.34 |
| CHEMBL4520001 | — | — | 1 | 5.32 |
| CHEMBL4581167 | — | — | 1 | 5.30 |
| CHEMBL4456742 | — | — | 1 | 5.24 |
| CHEMBL4437540 | — | — | 1 | 5.24 |
| CHEMBL4447518 | — | — | 1 | 5.22 |
| CHEMBL4555692 | — | — | 1 | 5.21 |
| CHEMBL4451794 | — | — | 1 | 5.21 |
| CHEMBL204374 | — | — | 1 | 5.20 |
| CHEMBL4472388 | — | — | 1 | 5.20 |
| CHEMBL4474043 | — | — | 1 | 5.19 |
| CHEMBL4543392 | — | — | 1 | 5.18 |
| CHEMBL4457528 | — | — | 1 | 5.18 |
| CHEMBL4535032 | — | — | 1 | 5.15 |
| CHEMBL4532600 | — | — | 1 | 5.13 |
| CHEMBL4449494 | — | — | 1 | 5.11 |
| CHEMBL4519764 | — | — | 1 | 5.09 |
| CHEMBL4442939 | — | — | 1 | 5.05 |
| CHEMBL4534682 | — | — | 1 | 5.03 |
| CHEMBL4439912 | — | — | 1 | 5.01 |
| CHEMBL77195 | — | — | 1 | 5.01 |
| CHEMBL4456120 | — | — | 1 | 4.98 |
| CHEMBL4471735 | — | — | 1 | 4.98 |
| CHEMBL4532956 | — | — | 1 | 4.98 |
| CHEMBL4437027 | — | — | 1 | 4.94 |
| CHEMBL4464670 | — | — | 1 | 4.93 |
| CHEMBL4449263 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471581 | — | EC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4437828 | — | EC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4589583 | — | EC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL290916 | EDARAVONE | EC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4520001 | — | EC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL4581167 | — | EC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL4456742 | — | EC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL4437540 | — | EC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL4447518 | — | EC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL4555692 | — | EC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL4451794 | — | EC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL4472388 | — | EC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL204374 | — | EC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4474043 | — | EC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL4457528 | — | EC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL4543392 | — | EC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL4535032 | — | EC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL4532600 | — | EC50 | = | 7460.0 | nM | 5.13 |
| CHEMBL4449494 | — | EC50 | = | 7810.0 | nM | 5.11 |
| CHEMBL4519764 | — | EC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL4442939 | — | EC50 | = | 8850.0 | nM | 5.05 |
| CHEMBL4534682 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4439912 | — | EC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL77195 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4456120 | — | EC50 | = | 10440.0 | nM | 4.98 |
| CHEMBL4471735 | — | EC50 | = | 10580.0 | nM | 4.98 |
| CHEMBL4532956 | — | EC50 | = | 10470.0 | nM | 4.98 |
| CHEMBL4437027 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4464670 | — | EC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL4449263 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL4448321 | — | EC50 | = | 12020.0 | nM | 4.92 |
| CHEMBL4542916 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4458445 | — | EC50 | = | 12530.0 | nM | 4.90 |
| CHEMBL4560515 | — | EC50 | = | 12930.0 | nM | 4.89 |
| CHEMBL4572346 | — | EC50 | = | 12760.0 | nM | 4.89 |
| CHEMBL4560140 | — | EC50 | = | 13130.0 | nM | 4.88 |
| CHEMBL4519064 | — | EC50 | = | 13490.0 | nM | 4.87 |
| CHEMBL4555598 | — | EC50 | = | 14510.0 | nM | 4.84 |
| CHEMBL4467256 | — | EC50 | = | 14630.0 | nM | 4.83 |
| CHEMBL303697 | LIGUSTRAZINE | EC50 | = | 15180.0 | nM | 4.82 |
| CHEMBL4471799 | — | EC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4563582 | — | EC50 | = | 15840.0 | nM | 4.80 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 16370.0 | nM | 4.79 |
| CHEMBL4560742 | — | EC50 | = | 18120.0 | nM | 4.74 |
| CHEMBL4438130 | — | EC50 | = | 21420.0 | nM | 4.67 |