Assay Detail
Functional
CHEMBL4409306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kappa opioid receptor (unknown origin) by [35S]-GTPgammaS binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress in the development of more effective and safer analgesics for pain management.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.59 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180639 | — | — | 1 | 8.30 |
| CHEMBL4458783 | — | — | 1 | 7.51 |
| CHEMBL2180638 | — | — | 1 | 7.43 |
| CHEMBL4435747 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180639 | — | EC50 | = | 4.98 | nM | 8.30 |
| CHEMBL4458783 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2180638 | — | EC50 | = | 36.7 | nM | 7.43 |
| CHEMBL4435747 | — | EC50 | = | 75.5 | nM | 7.12 |