Assay Detail
Functional
CHEMBL4409350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kappa opioid receptor (unknown origin) in presence of DAMGO by [35S]-GTPgammaS binding assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress in the development of more effective and safer analgesics for pain management.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.81 | 8.85 |
| IC50 | 1 | 6.88 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458337 | — | — | 1 | 8.85 |
| CHEMBL58362 | — | — | 2 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458337 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL58362 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL58362 | — | IC50 | = | 131.83 | nM | 6.88 |