Assay Detail
ADMET
CHEMBL4409391
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure based design, synthesis and in vitro antitumour activity of tiazofurin stereoisomers with nitrogen functions at the C-2' or C-3' positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.83 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.00 |
| CHEMBL108358 | TIAZOFURIN | 2.0 | 1 | 6.44 |
| CHEMBL4536894 | — | — | 1 | 5.49 |
| CHEMBL375197 | — | — | 1 | 4.37 |
| CHEMBL219331 | — | — | 1 | - |
| CHEMBL4452782 | — | — | 1 | - |
| CHEMBL4583780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL108358 | TIAZOFURIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4536894 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL375197 | — | IC50 | = | 42350.0 | nM | 4.37 |
| CHEMBL219331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4452782 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4583780 | — | IC50 | > | 100000.0 | nM | - |