Assay Detail
Binding
CHEMBL4409428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His8-tagged IDH1 R132C mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition and measured for 60 mins in presence of NADPH by diaphorase/resazurin-based fluorescence assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP] cytoplasmic (CHEMBL2007625) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.49 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474186 | — | — | 1 | 8.10 |
| CHEMBL4568616 | — | — | 1 | 8.09 |
| CHEMBL4444067 | — | — | 1 | 8.03 |
| CHEMBL4475715 | — | — | 1 | 8.03 |
| CHEMBL4567884 | — | — | 1 | 8.01 |
| CHEMBL4451801 | — | — | 1 | 7.85 |
| CHEMBL4469477 | — | — | 1 | 7.84 |
| CHEMBL4570265 | — | — | 1 | 7.82 |
| CHEMBL4467991 | — | — | 1 | 7.82 |
| CHEMBL4537907 | — | — | 1 | 7.79 |
| CHEMBL4529476 | — | — | 1 | 7.77 |
| CHEMBL4476025 | — | — | 1 | 7.76 |
| CHEMBL4541801 | — | — | 1 | 7.73 |
| CHEMBL3989958 | IVOSIDENIB | 4.0 | 1 | 7.64 |
| CHEMBL4548637 | — | — | 1 | 7.63 |
| CHEMBL4455559 | — | — | 1 | 7.62 |
| CHEMBL4445771 | — | — | 1 | 7.61 |
| CHEMBL4592898 | — | — | 1 | 7.36 |
| CHEMBL4546041 | — | — | 1 | 7.35 |
| CHEMBL3947537 | — | — | 1 | 7.30 |
| CHEMBL4553096 | — | — | 1 | 7.09 |
| CHEMBL4532585 | — | — | 1 | 7.03 |
| CHEMBL4455018 | — | — | 1 | 6.92 |
| CHEMBL4470532 | — | — | 1 | 6.81 |
| CHEMBL4575435 | — | — | 1 | 6.41 |
| CHEMBL4474717 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474186 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4568616 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4444067 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4475715 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4567884 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4451801 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL4469477 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL4570265 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4467991 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4537907 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL4529476 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4476025 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL4541801 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL3989958 | IVOSIDENIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4548637 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL4455559 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL4445771 | — | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL4592898 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL4546041 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL3947537 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL4553096 | — | IC50 | = | 81.9 | nM | 7.09 |
| CHEMBL4532585 | — | IC50 | = | 93.5 | nM | 7.03 |
| CHEMBL4455018 | — | IC50 | = | 119.1 | nM | 6.92 |
| CHEMBL4470532 | — | IC50 | = | 153.8 | nM | 6.81 |
| CHEMBL4575435 | — | IC50 | = | 393.9 | nM | 6.41 |
| CHEMBL4474717 | — | IC50 | = | 5858.0 | nM | 5.23 |