Assay Detail
Binding
CHEMBL4409429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His8-tagged IDH1 R132H mutant expressed in Escherichia coli BL21 assessed as reduction in NADPH consumption using alpha-ketoglutarate as substrate preincubated for 60 mins followed by substrate addition measured for 60 mins in presence of NADPH by diaphorase/resazurin-based assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Isocitrate dehydrogenase [NADP] cytoplasmic (CHEMBL2007625) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new small molecule inhibitors targeting isocitrate dehydrogenase 1 (IDH1) with blood-brain barrier penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.76 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444067 | — | — | 1 | 9.00 |
| CHEMBL4529476 | — | — | 1 | 8.68 |
| CHEMBL4548637 | — | — | 1 | 8.67 |
| CHEMBL4469477 | — | — | 1 | 8.66 |
| CHEMBL4467991 | — | — | 1 | 8.64 |
| CHEMBL4475715 | — | — | 1 | 8.57 |
| CHEMBL3989958 | IVOSIDENIB | 4.0 | 1 | 8.46 |
| CHEMBL4568616 | — | — | 1 | 8.40 |
| CHEMBL4451801 | — | — | 1 | 7.81 |
| CHEMBL4474186 | — | — | 1 | 7.74 |
| CHEMBL4476025 | — | — | 1 | 7.72 |
| CHEMBL4553096 | — | — | 1 | 7.62 |
| CHEMBL4455559 | — | — | 1 | 7.62 |
| CHEMBL4445771 | — | — | 1 | 7.48 |
| CHEMBL4567884 | — | — | 1 | 7.47 |
| CHEMBL4570265 | — | — | 1 | 7.38 |
| CHEMBL4537907 | — | — | 1 | 7.37 |
| CHEMBL4592898 | — | — | 1 | 7.35 |
| CHEMBL4546041 | — | — | 1 | 7.32 |
| CHEMBL3947537 | — | — | 1 | 7.30 |
| CHEMBL4541801 | — | — | 1 | 7.29 |
| CHEMBL4470532 | — | — | 1 | 7.21 |
| CHEMBL4455018 | — | — | 1 | 6.92 |
| CHEMBL4532585 | — | — | 1 | 6.89 |
| CHEMBL4575435 | — | — | 1 | 6.32 |
| CHEMBL4474717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444067 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4529476 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4548637 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL4469477 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4467991 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4475715 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3989958 | IVOSIDENIB | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4568616 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4451801 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4474186 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL4476025 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL4553096 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL4455559 | — | IC50 | = | 23.8 | nM | 7.62 |
| CHEMBL4445771 | — | IC50 | = | 33.4 | nM | 7.48 |
| CHEMBL4567884 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL4570265 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4537907 | — | IC50 | = | 42.7 | nM | 7.37 |
| CHEMBL4592898 | — | IC50 | = | 44.3 | nM | 7.35 |
| CHEMBL4546041 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL3947537 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL4541801 | — | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL4470532 | — | IC50 | = | 61.9 | nM | 7.21 |
| CHEMBL4455018 | — | IC50 | = | 119.8 | nM | 6.92 |
| CHEMBL4532585 | — | IC50 | = | 128.5 | nM | 6.89 |
| CHEMBL4575435 | — | IC50 | = | 478.5 | nM | 6.32 |
| CHEMBL4474717 | — | IC50 | > | 10000.0 | nM | - |