Assay Detail
Functional
CHEMBL4409474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Cytomegalovirus AD169 infected in human HELF cells assessed as reduction in virus-induced cytopathogenicity incubated for 7 days by Giemsa staining based microscopic analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cytomegalovirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.05 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.37 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.50 |
| CHEMBL4465508 | — | — | 1 | 5.05 |
| CHEMBL3299017 | — | — | 1 | 5.05 |
| CHEMBL4451587 | — | — | 1 | 5.03 |
| CHEMBL4475221 | — | — | 1 | 5.03 |
| CHEMBL4538303 | — | — | 1 | 4.70 |
| CHEMBL4532325 | — | — | 1 | 4.35 |
| CHEMBL4582139 | — | — | 1 | 4.35 |
| CHEMBL4518370 | — | — | 1 | - |
| CHEMBL4457582 | — | — | 1 | - |
| CHEMBL4567127 | — | — | 1 | - |
| CHEMBL4470222 | — | — | 1 | - |
| CHEMBL4517740 | — | — | 1 | - |
| CHEMBL4566092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL4465508 | — | EC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL3299017 | — | EC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL4451587 | — | EC50 | = | 9360.0 | nM | 5.03 |
| CHEMBL4475221 | — | EC50 | = | 9360.0 | nM | 5.03 |
| CHEMBL4538303 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4532325 | — | EC50 | = | 44720.0 | nM | 4.35 |
| CHEMBL4582139 | — | EC50 | = | 44720.0 | nM | 4.35 |
| CHEMBL4518370 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4457582 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4567127 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4470222 | — | EC50 | > | 4000.0 | nM | - |
| CHEMBL4517740 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4566092 | — | EC50 | > | 100000.0 | nM | - |