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Assay Detail

CHEMBL4409577

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MGC803 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MGC-803
Confidence 1 — Organism
Curated By Autocuration

Target

MGC-803 (CHEMBL3706566)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent.
He Z, Qiao H, Yang F, Zhou W, Gong Y, Zhang X, Wang H, Zhao B, Ma L, Liu HM, Zhao W.
Eur J Med Chem (2019) 184 : 111764 -111764
PubMed 31614257 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.39 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4465939 1 6.48
CHEMBL4584971 1 6.27
CHEMBL4517558 1 6.05
CHEMBL4442736 1 5.83
CHEMBL4471139 1 5.65
CHEMBL4435624 1 5.65
CHEMBL4555674 1 5.61
CHEMBL4555006 1 5.55
CHEMBL4446211 1 5.55
CHEMBL4471959 1 5.53
CHEMBL4517765 1 5.43
CHEMBL4471607 1 5.38
CHEMBL4514626 1 5.16
CHEMBL4445007 1 5.15
CHEMBL4528383 1 5.11
CHEMBL1765796 1 5.04
CHEMBL4584496 1 5.00
CHEMBL4579204 1 4.97
CHEMBL4585378 1 4.91
CHEMBL4562961 1 4.80
CHEMBL4566819 1 4.79
CHEMBL4452359 1 4.65
CHEMBL4530912 1 -
CHEMBL4450815 1 -
CHEMBL4543857 1 -
CHEMBL4469362 1 -
CHEMBL4513959 1 -
CHEMBL4565261 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4465939 IC50 = 330.0 nM 6.48
CHEMBL4584971 IC50 = 540.0 nM 6.27
CHEMBL4517558 IC50 = 890.0 nM 6.05
CHEMBL4442736 IC50 = 1490.0 nM 5.83
CHEMBL4471139 IC50 = 2230.0 nM 5.65
CHEMBL4435624 IC50 = 2240.0 nM 5.65
CHEMBL4555674 IC50 = 2480.0 nM 5.61
CHEMBL4555006 IC50 = 2820.0 nM 5.55
CHEMBL4446211 IC50 = 2810.0 nM 5.55
CHEMBL4471959 IC50 = 2940.0 nM 5.53
CHEMBL4517765 IC50 = 3740.0 nM 5.43
CHEMBL4471607 IC50 = 4200.0 nM 5.38
CHEMBL4514626 IC50 = 6860.0 nM 5.16
CHEMBL4445007 IC50 = 7080.0 nM 5.15
CHEMBL4528383 IC50 = 7780.0 nM 5.11
CHEMBL1765796 IC50 = 9140.0 nM 5.04
CHEMBL4584496 IC50 = 9960.0 nM 5.00
CHEMBL4579204 IC50 = 10770.0 nM 4.97
CHEMBL4585378 IC50 = 12240.0 nM 4.91
CHEMBL4562961 IC50 = 15940.0 nM 4.80
CHEMBL4566819 IC50 = 16280.0 nM 4.79
CHEMBL4452359 IC50 = 22310.0 nM 4.65
CHEMBL4530912 IC50 > 20000.0 nM -
CHEMBL4450815 IC50 > 20000.0 nM -
CHEMBL4543857 IC50 > 20000.0 nM -
CHEMBL4469362 IC50 > 20000.0 nM -
CHEMBL4513959 IC50 > 20000.0 nM -
CHEMBL4565261 IC50 > 20000.0 nM -