Assay Detail
Functional
CHEMBL4409792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative against human K562 cells incubated for 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological research of novel N-phenylbenzamide-4-methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.89 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.15 |
| CHEMBL4576520 | — | — | 1 | 6.04 |
| CHEMBL4472594 | — | — | 1 | 5.91 |
| CHEMBL4514128 | — | — | 1 | 5.88 |
| CHEMBL4436521 | — | — | 1 | 5.84 |
| CHEMBL4567454 | — | — | 1 | 5.81 |
| CHEMBL4472573 | — | — | 1 | 5.62 |
| CHEMBL4443373 | — | — | 1 | - |
| CHEMBL149837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4576520 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4472594 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4514128 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4436521 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4567454 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4472573 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4443373 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL149837 | — | IC50 | > | 10000.0 | nM | - |