Assay Detail
Binding
CHEMBL4409966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kinesin (unknown origin) assessed as reduction in ATPase activity using microtubule as substrate measured for 5 to mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.38 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213953 | — | — | 1 | 7.00 |
| CHEMBL4473803 | — | — | 1 | 5.41 |
| CHEMBL4525171 | — | — | 1 | 5.40 |
| CHEMBL4587172 | — | — | 1 | 5.36 |
| CHEMBL4435772 | — | — | 1 | 4.97 |
| CHEMBL4584749 | — | — | 1 | 4.85 |
| CHEMBL236789 | MONASTROL | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213953 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4473803 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4525171 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL4587172 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL4435772 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL4584749 | — | IC50 | = | 14070.0 | nM | 4.85 |
| CHEMBL236789 | MONASTROL | IC50 | = | 20000.0 | nM | 4.70 |