Assay Detail
Binding
CHEMBL4409976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged Eg5 (1 to 368 residues) assessed as reduction in ATPase activity by Bradford reagent based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.13 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213953 | — | — | 1 | 7.00 |
| CHEMBL394880 | DIMETHYLENASTRON | — | 1 | 6.70 |
| CHEMBL236789 | MONASTROL | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213953 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL394880 | DIMETHYLENASTRON | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL236789 | MONASTROL | IC50 | = | 20000.0 | nM | 4.70 |