Assay Detail
Binding
CHEMBL4410510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 68 | 7.01 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176219 | — | — | 1 | 9.77 |
| CHEMBL176159 | — | — | 1 | 9.51 |
| CHEMBL178997 | — | — | 1 | 9.39 |
| CHEMBL175993 | — | — | 1 | 9.06 |
| CHEMBL361215 | — | — | 1 | 9.01 |
| CHEMBL367532 | — | — | 1 | 8.92 |
| CHEMBL179437 | — | — | 1 | 8.92 |
| CHEMBL215030 | — | — | 1 | 8.66 |
| CHEMBL179353 | — | — | 1 | 8.66 |
| CHEMBL176548 | — | — | 1 | 8.59 |
| CHEMBL367156 | — | — | 1 | 8.51 |
| CHEMBL209109 | — | — | 1 | 8.46 |
| CHEMBL377843 | — | — | 1 | 8.32 |
| CHEMBL4465399 | — | — | 1 | 8.31 |
| CHEMBL190780 | — | — | 1 | 8.28 |
| CHEMBL2112988 | — | — | 1 | 8.27 |
| CHEMBL360731 | — | — | 1 | 8.26 |
| CHEMBL4444299 | — | — | 1 | 8.17 |
| CHEMBL182150 | — | — | 1 | 8.08 |
| CHEMBL429895 | — | — | 1 | 7.99 |
| CHEMBL377864 | — | — | 1 | 7.70 |
| CHEMBL215964 | — | — | 1 | 7.68 |
| CHEMBL214432 | — | — | 1 | 7.62 |
| CHEMBL176024 | — | — | 1 | 7.62 |
| CHEMBL175860 | — | — | 1 | 7.41 |
| CHEMBL4476156 | — | — | 1 | 7.40 |
| CHEMBL208635 | — | — | 1 | 7.36 |
| CHEMBL179325 | — | — | 1 | 7.30 |
| CHEMBL386039 | — | — | 1 | 7.15 |
| CHEMBL217605 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176219 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL176159 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL178997 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL175993 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL361215 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL367532 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL179437 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL215030 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL179353 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL176548 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL367156 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL209109 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL377843 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4465399 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL190780 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2112988 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL360731 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4444299 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL182150 | — | IC50 | = | 8.28 | nM | 8.08 |
| CHEMBL429895 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL377864 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL215964 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL214432 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL176024 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL175860 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4476156 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL208635 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL179325 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL386039 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL217605 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL379802 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL550545 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4461504 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4460423 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL212254 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL378261 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL267320 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL424895 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL217196 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4571110 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL562016 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL179872 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL370222 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL175874 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL213771 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL214858 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL268385 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL425445 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL217860 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4524539 | — | IC50 | = | 890.0 | nM | 6.05 |