Assay Detail
ADMET
CHEMBL4410522
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Cytotoxicity against human MDA-MB-231 cells measured after 48 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.55 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473654 | — | — | 1 | 5.55 |
| CHEMBL4513418 | — | — | 1 | - |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473654 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4513418 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL945 | AMILORIDE | IC50 | > | 100000.0 | nM | - |