Assay Detail
Binding
CHEMBL4410552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at histamine H1 receptor (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H1 antagonize activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.91 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172 | DESLORATADINE | 4.0 | 1 | 8.73 |
| CHEMBL4446961 | — | — | 1 | 8.53 |
| CHEMBL4591702 | — | — | 1 | 8.44 |
| CHEMBL4467816 | — | — | 1 | 8.34 |
| CHEMBL4556553 | — | — | 1 | 8.32 |
| CHEMBL4587694 | — | — | 1 | 8.21 |
| CHEMBL4451332 | — | — | 1 | 8.09 |
| CHEMBL4539150 | — | — | 1 | 8.05 |
| CHEMBL4473466 | — | — | 1 | 8.03 |
| CHEMBL4581995 | — | — | 1 | 7.92 |
| CHEMBL4473399 | — | — | 1 | 7.75 |
| CHEMBL4518271 | — | — | 1 | 7.68 |
| CHEMBL4539056 | — | — | 1 | 7.55 |
| CHEMBL4529928 | — | — | 1 | 7.55 |
| CHEMBL4557928 | — | — | 1 | 7.43 |
| CHEMBL4458953 | — | — | 1 | 7.40 |
| CHEMBL4445636 | — | — | 1 | 7.28 |
| CHEMBL4565774 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172 | DESLORATADINE | IC50 | = | 1.84 | nM | 8.73 |
| CHEMBL4446961 | — | IC50 | = | 2.95 | nM | 8.53 |
| CHEMBL4591702 | — | IC50 | = | 3.67 | nM | 8.44 |
| CHEMBL4467816 | — | IC50 | = | 4.56 | nM | 8.34 |
| CHEMBL4556553 | — | IC50 | = | 4.74 | nM | 8.32 |
| CHEMBL4587694 | — | IC50 | = | 6.23 | nM | 8.21 |
| CHEMBL4451332 | — | IC50 | = | 8.14 | nM | 8.09 |
| CHEMBL4539150 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4473466 | — | IC50 | = | 9.28 | nM | 8.03 |
| CHEMBL4581995 | — | IC50 | = | 11.97 | nM | 7.92 |
| CHEMBL4473399 | — | IC50 | = | 17.65 | nM | 7.75 |
| CHEMBL4518271 | — | IC50 | = | 20.98 | nM | 7.68 |
| CHEMBL4539056 | — | IC50 | = | 28.41 | nM | 7.55 |
| CHEMBL4529928 | — | IC50 | = | 27.88 | nM | 7.55 |
| CHEMBL4557928 | — | IC50 | = | 36.71 | nM | 7.43 |
| CHEMBL4458953 | — | IC50 | = | 40.22 | nM | 7.40 |
| CHEMBL4445636 | — | IC50 | = | 52.85 | nM | 7.28 |
| CHEMBL4565774 | — | IC50 | = | 81.78 | nM | 7.09 |