Assay Detail
Binding
CHEMBL4410607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Plasmodium falciparum dihydrofolate reductase N51I/C59R/S108N/I164L quadruple mutant expressed in Escherichia coli BL21(DE3)pLysS using dihydrofolate as substrate in presence of NADPH by UV-vis spectrophotometry analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.40 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590684 | — | — | 1 | 9.39 |
| CHEMBL4452609 | — | — | 1 | 9.30 |
| CHEMBL4447272 | — | — | 1 | 9.14 |
| CHEMBL4462327 | — | — | 1 | 9.03 |
| CHEMBL4461699 | — | — | 1 | 9.01 |
| CHEMBL4588852 | — | — | 1 | 8.98 |
| CHEMBL4565928 | — | — | 1 | 8.94 |
| CHEMBL4546946 | — | — | 1 | 8.91 |
| CHEMBL4586252 | — | — | 1 | 8.90 |
| CHEMBL4553483 | — | — | 1 | 8.86 |
| CHEMBL4558959 | — | — | 1 | 8.83 |
| CHEMBL4526752 | — | — | 1 | 8.76 |
| CHEMBL4459902 | — | — | 1 | 8.51 |
| CHEMBL4437388 | — | — | 1 | 8.49 |
| CHEMBL278847 | — | — | 1 | 8.48 |
| CHEMBL4467953 | — | — | 1 | 8.44 |
| CHEMBL4566524 | — | — | 1 | 8.30 |
| CHEMBL4468791 | — | — | 1 | 8.30 |
| CHEMBL4444614 | — | — | 1 | 8.12 |
| CHEMBL4515405 | — | — | 1 | 8.06 |
| CHEMBL4456065 | — | — | 1 | 7.80 |
| CHEMBL4441455 | — | — | 1 | 7.77 |
| CHEMBL4557136 | — | — | 1 | 7.65 |
| CHEMBL4459356 | — | — | 1 | 7.56 |
| CHEMBL22148 | — | — | 1 | 7.50 |
| CHEMBL4542001 | — | — | 1 | 7.48 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590684 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL4452609 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4447272 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL4462327 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL4461699 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL4588852 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL4565928 | — | Ki | = | 1.16 | nM | 8.94 |
| CHEMBL4546946 | — | Ki | = | 1.24 | nM | 8.91 |
| CHEMBL4586252 | — | Ki | = | 1.26 | nM | 8.90 |
| CHEMBL4553483 | — | Ki | = | 1.37 | nM | 8.86 |
| CHEMBL4558959 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL4526752 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL4459902 | — | Ki | = | 3.06 | nM | 8.51 |
| CHEMBL4437388 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL278847 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4467953 | — | Ki | = | 3.61 | nM | 8.44 |
| CHEMBL4566524 | — | Ki | = | 5.04 | nM | 8.30 |
| CHEMBL4468791 | — | Ki | = | 4.96 | nM | 8.30 |
| CHEMBL4444614 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL4515405 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL4456065 | — | Ki | = | 15.89 | nM | 7.80 |
| CHEMBL4441455 | — | Ki | = | 17.08 | nM | 7.77 |
| CHEMBL4557136 | — | Ki | = | 22.44 | nM | 7.65 |
| CHEMBL4459356 | — | Ki | = | 27.48 | nM | 7.56 |
| CHEMBL22148 | — | Ki | = | 31.9 | nM | 7.50 |
| CHEMBL4542001 | — | Ki | = | 33.32 | nM | 7.48 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 385.0 | nM | 6.42 |