Assay Detail
ADMET
CHEMBL4410612
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human dihydrofolate reductase using dihydrofolate as substrate in presence of NADPH by UV-vis spectrophotometry analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.58 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278847 | — | — | 1 | 8.80 |
| CHEMBL4565928 | — | — | 1 | 8.06 |
| CHEMBL22148 | — | — | 1 | 7.98 |
| CHEMBL4553483 | — | — | 1 | 7.90 |
| CHEMBL4558959 | — | — | 1 | 7.89 |
| CHEMBL4447272 | — | — | 1 | 7.87 |
| CHEMBL4590684 | — | — | 1 | 7.87 |
| CHEMBL4459902 | — | — | 1 | 7.84 |
| CHEMBL4452609 | — | — | 1 | 7.74 |
| CHEMBL4437388 | — | — | 1 | 7.74 |
| CHEMBL4461699 | — | — | 1 | 7.71 |
| CHEMBL4462327 | — | — | 1 | 7.66 |
| CHEMBL4515405 | — | — | 1 | 7.66 |
| CHEMBL4444614 | — | — | 1 | 7.63 |
| CHEMBL4557136 | — | — | 1 | 7.56 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.55 |
| CHEMBL4586252 | — | — | 1 | 7.54 |
| CHEMBL4542001 | — | — | 1 | 7.49 |
| CHEMBL4467953 | — | — | 1 | 7.48 |
| CHEMBL4546946 | — | — | 1 | 7.46 |
| CHEMBL4588852 | — | — | 1 | 7.34 |
| CHEMBL4526752 | — | — | 1 | 7.31 |
| CHEMBL4566524 | — | — | 1 | 7.28 |
| CHEMBL4468791 | — | — | 1 | 7.13 |
| CHEMBL4459356 | — | — | 1 | 6.29 |
| CHEMBL4441455 | — | — | 1 | 6.25 |
| CHEMBL4456065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278847 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4565928 | — | Ki | = | 8.72 | nM | 8.06 |
| CHEMBL22148 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL4553483 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL4558959 | — | Ki | = | 12.77 | nM | 7.89 |
| CHEMBL4447272 | — | Ki | = | 13.41 | nM | 7.87 |
| CHEMBL4590684 | — | Ki | = | 13.59 | nM | 7.87 |
| CHEMBL4459902 | — | Ki | = | 14.36 | nM | 7.84 |
| CHEMBL4452609 | — | Ki | = | 18.24 | nM | 7.74 |
| CHEMBL4437388 | — | Ki | = | 18.41 | nM | 7.74 |
| CHEMBL4461699 | — | Ki | = | 19.55 | nM | 7.71 |
| CHEMBL4462327 | — | Ki | = | 21.72 | nM | 7.66 |
| CHEMBL4515405 | — | Ki | = | 22.07 | nM | 7.66 |
| CHEMBL4444614 | — | Ki | = | 23.42 | nM | 7.63 |
| CHEMBL4557136 | — | Ki | = | 27.27 | nM | 7.56 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL4586252 | — | Ki | = | 29.05 | nM | 7.54 |
| CHEMBL4542001 | — | Ki | = | 32.43 | nM | 7.49 |
| CHEMBL4467953 | — | Ki | = | 32.89 | nM | 7.48 |
| CHEMBL4546946 | — | Ki | = | 34.84 | nM | 7.46 |
| CHEMBL4588852 | — | Ki | = | 45.97 | nM | 7.34 |
| CHEMBL4526752 | — | Ki | = | 48.67 | nM | 7.31 |
| CHEMBL4566524 | — | Ki | = | 52.39 | nM | 7.28 |
| CHEMBL4468791 | — | Ki | = | 74.16 | nM | 7.13 |
| CHEMBL4459356 | — | Ki | = | 508.88 | nM | 6.29 |
| CHEMBL4441455 | — | Ki | = | 555.55 | nM | 6.25 |
| CHEMBL4456065 | — | Ki | - | — | - |