Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4410619

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum.
Saepua S, Sadorn K, Vanichtanankul J, Anukunwithaya T, Rattanajak R, Vitsupakorn D, Kamchonwongpaisan S, Yuthavong Y, Thongpanchang C.
Bioorg Med Chem (2019) 27 : 115158 -115158
PubMed 31685330 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.45 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4459902 1 6.40
CHEMBL4565928 1 6.33
CHEMBL4456065 1 6.19
CHEMBL4553483 1 5.86
CHEMBL4515405 1 5.73
CHEMBL4557136 1 5.30
CHEMBL4558959 1 5.29
CHEMBL278847 1 5.16
CHEMBL4437388 1 5.14
CHEMBL4467953 1 5.10
CHEMBL4444614 1 5.09
CHEMBL4526752 1 4.81
CHEMBL36 PYRIMETHAMINE 4.0 1 4.50
CHEMBL22148 1 -
CHEMBL4542001 1 -
CHEMBL4459356 1 -
CHEMBL4566524 1 -
CHEMBL4441455 1 -
CHEMBL4468791 1 -
CHEMBL4452609 1 -
CHEMBL4590684 1 -
CHEMBL4588852 1 -
CHEMBL4447272 1 -
CHEMBL4586252 1 -
CHEMBL4461699 1 -
CHEMBL4462327 1 -
CHEMBL4546946 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4459902 IC50 = 400.0 nM 6.40
CHEMBL4565928 IC50 = 470.0 nM 6.33
CHEMBL4456065 IC50 = 650.0 nM 6.19
CHEMBL4553483 IC50 = 1390.0 nM 5.86
CHEMBL4515405 IC50 = 1870.0 nM 5.73
CHEMBL4557136 IC50 = 4960.0 nM 5.30
CHEMBL4558959 IC50 = 5150.0 nM 5.29
CHEMBL278847 IC50 = 7000.0 nM 5.16
CHEMBL4437388 IC50 = 7210.0 nM 5.14
CHEMBL4467953 IC50 = 7910.0 nM 5.10
CHEMBL4444614 IC50 = 8130.0 nM 5.09
CHEMBL4526752 IC50 = 15380.0 nM 4.81
CHEMBL36 PYRIMETHAMINE IC50 = 32000.0 nM 4.50
CHEMBL22148 IC50 - -
CHEMBL4542001 IC50 > 10000.0 nM -
CHEMBL4459356 IC50 > 100000.0 nM -
CHEMBL4566524 IC50 > 10000.0 nM -
CHEMBL4441455 IC50 > 50000.0 nM -
CHEMBL4468791 IC50 > 100000.0 nM -
CHEMBL4452609 IC50 > 10000.0 nM -
CHEMBL4590684 IC50 > 50000.0 nM -
CHEMBL4588852 IC50 > 1000.0 nM -
CHEMBL4447272 IC50 > 50000.0 nM -
CHEMBL4586252 IC50 > 25000.0 nM -
CHEMBL4461699 IC50 > 10000.0 nM -
CHEMBL4462327 IC50 > 100000.0 nM -
CHEMBL4546946 IC50 > 100000.0 nM -