Assay Detail
Binding
CHEMBL4410697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidepressant-like activity of novel alkoxy-piperidine derivatives targeting SSRI/5-HT1A/5-HT7.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.55 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444213 | — | — | 1 | 7.60 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 7.58 |
| CHEMBL4472767 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444213 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2104993 | VORTIOXETINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4472767 | — | Ki | = | 35.0 | nM | 7.46 |