Assay Detail
Functional
CHEMBL4410741
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Antiallergic activity in rat RBL2H3 cells assessed as inhibition of C48/80-induced mast cell degranulation preincubated with compound for 30 mins and then treated with C48/80 for 1 hr by neutral red dye based method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activity of a novel ethylenediamine derivatives as H1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.89 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4462043 | — | — | 1 | 7.97 |
| CHEMBL4576383 | — | — | 1 | 7.74 |
| CHEMBL4438743 | — | — | 1 | 7.54 |
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | 7.50 |
| CHEMBL4444270 | — | — | 1 | 7.34 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 7.27 |
| CHEMBL4546089 | — | — | 1 | 7.26 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 7.09 |
| CHEMBL4545003 | — | — | 1 | 7.08 |
| CHEMBL4437364 | — | — | 1 | 7.05 |
| CHEMBL4529352 | — | — | 1 | 6.89 |
| CHEMBL320650 | — | — | 1 | 6.84 |
| CHEMBL4465483 | — | — | 1 | 6.82 |
| CHEMBL4543689 | — | — | 1 | 6.51 |
| CHEMBL4472820 | — | — | 1 | 5.92 |
| CHEMBL4442571 | — | — | 1 | 5.87 |
| CHEMBL4446125 | — | — | 1 | 5.65 |
| CHEMBL4474062 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4462043 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL4576383 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL4438743 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL505 | CHLORPHENIRAMINE | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL4444270 | — | IC50 | = | 45.3 | nM | 7.34 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 53.3 | nM | 7.27 |
| CHEMBL4546089 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL511 | PYRILAMINE | IC50 | = | 81.5 | nM | 7.09 |
| CHEMBL4545003 | — | IC50 | = | 83.9 | nM | 7.08 |
| CHEMBL4437364 | — | IC50 | = | 89.2 | nM | 7.05 |
| CHEMBL4529352 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL320650 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4465483 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4543689 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4472820 | — | IC50 | = | 1206.0 | nM | 5.92 |
| CHEMBL4442571 | — | IC50 | = | 1338.0 | nM | 5.87 |
| CHEMBL4446125 | — | IC50 | = | 2228.0 | nM | 5.65 |
| CHEMBL4474062 | — | IC50 | = | 2310.0 | nM | 5.64 |