Assay Detail
Functional
CHEMBL4410834
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Antiproliferative activity against human COR-L23 cells incubated for 72 hrs by CellTiterGlo assay
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COR-L23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.27 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213004 | — | — | 1 | 8.51 |
| CHEMBL4438525 | — | — | 1 | 8.49 |
| CHEMBL4450629 | — | — | 1 | 8.41 |
| CHEMBL4558559 | — | — | 1 | 8.37 |
| CHEMBL4446132 | — | — | 1 | 8.30 |
| CHEMBL4483695 | — | — | 1 | 8.10 |
| CHEMBL4536277 | — | — | 1 | 8.00 |
| CHEMBL4448916 | — | — | 1 | 8.00 |
| CHEMBL4556614 | — | — | 1 | 7.72 |
| CHEMBL4561577 | — | — | 1 | 7.57 |
| CHEMBL4546918 | — | — | 1 | 7.54 |
| CHEMBL4205098 | — | — | 1 | 7.46 |
| CHEMBL4456070 | — | — | 1 | 7.42 |
| CHEMBL4457730 | — | — | 1 | 7.39 |
| CHEMBL4586676 | — | — | 1 | 7.24 |
| CHEMBL4441045 | — | — | 1 | 6.96 |
| CHEMBL4451769 | — | — | 1 | 6.92 |
| CHEMBL4571655 | — | — | 1 | 6.92 |
| CHEMBL4469631 | — | — | 1 | 6.89 |
| CHEMBL4532502 | — | — | 1 | 6.89 |
| CHEMBL4575553 | — | — | 1 | 6.80 |
| CHEMBL4439536 | — | — | 1 | 6.70 |
| CHEMBL4444464 | — | — | 1 | 6.20 |
| CHEMBL4540185 | — | — | 1 | 6.01 |
| CHEMBL4561390 | — | — | 1 | 5.94 |
| CHEMBL4552727 | — | — | 1 | 5.86 |
| CHEMBL4541056 | — | — | 1 | 5.80 |
| CHEMBL4446579 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213004 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4438525 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4450629 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4558559 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4446132 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4483695 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4448916 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4536277 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4556614 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4561577 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4546918 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4205098 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4456070 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4457730 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4586676 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4441045 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4571655 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4451769 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4469631 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4532502 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4575553 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4439536 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4444464 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4540185 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4561390 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4552727 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4541056 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4446579 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL4446579 | — | IC50 | > | 2500.0 | nM | - |