Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4411035

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activation of NF-KappaB (unknown origin) expressed in SH-SY5Y cells co-transfected with pNFkappaB-Luc plasmid measured after 24 hrs by Bright-Glo luciferase assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type SH-SY5Y
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Approaches for Prevention and Treatment of Neurodegenerative Diseases: ALS and Alzheimer's.
Kargbo RB.
ACS Med Chem Lett (2019) 10 : 1588 -1589
PubMed 31857831 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 6.22 6.80
ECmax 8 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4535691 2 6.80
CHEMBL528694 2 6.68
CHEMBL4465283 2 6.40
CHEMBL1370490 2 6.30
CHEMBL4474207 2 6.15
CHEMBL4588896 2 5.99
CHEMBL4572792 2 5.92
CHEMBL4476647 2 5.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4535691 EC50 = 160.0 nM 6.80
CHEMBL528694 EC50 = 210.0 nM 6.68
CHEMBL4465283 EC50 = 400.0 nM 6.40
CHEMBL1370490 EC50 = 500.0 nM 6.30
CHEMBL4474207 EC50 = 710.0 nM 6.15
CHEMBL4588896 EC50 = 1030.0 nM 5.99
CHEMBL4572792 EC50 = 1200.0 nM 5.92
CHEMBL4476647 EC50 = 3270.0 nM 5.49
CHEMBL4535691 ECmax = 42.58 uM -
CHEMBL4474207 ECmax = 20.15 uM -
CHEMBL4572792 ECmax = 63.18 uM -
CHEMBL4465283 ECmax = 34.11 uM -
CHEMBL1370490 ECmax = 26.0 uM -
CHEMBL528694 ECmax = 40.0 uM -
CHEMBL4588896 ECmax = 23.53 uM -
CHEMBL4476647 ECmax = 46.45 uM -