Assay Detail
Binding
CHEMBL4411105
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Inhibition of bovine GRK6 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.53 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464632 | — | — | 1 | 6.39 |
| CHEMBL4557065 | — | — | 1 | 5.75 |
| CHEMBL4592746 | — | — | 1 | 5.60 |
| CHEMBL4576822 | — | — | 1 | 5.58 |
| CHEMBL4447191 | — | — | 1 | 5.11 |
| CHEMBL4456130 | — | — | 1 | 4.75 |
| CHEMBL4543927 | — | — | 1 | - |
| CHEMBL4536595 | — | — | 1 | - |
| CHEMBL4578499 | — | — | 1 | - |
| CHEMBL4517792 | — | — | 1 | - |
| CHEMBL4569321 | — | — | 1 | - |
| CHEMBL4524355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464632 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4557065 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4592746 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4576822 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4447191 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4456130 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4543927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4536595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4578499 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4517792 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4569321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4524355 | — | IC50 | > | 100000.0 | nM | - |