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Assay Detail

CHEMBL4411355

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mushroom tyrosinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agaricus bisporus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosinase (CHEMBL3318)
Type SINGLE PROTEIN
Organism Agaricus bisporus

Publication

Inhibitors of Melanogenesis: An Updated Review.
Pillaiyar T, Namasivayam V, Manickam M, Jung SH.
J Med Chem (2018) 61 : 7395 -7418
PubMed 29763564 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 5.33 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1275999 GAMMA-THUJAPLICIN 1 7.16
CHEMBL48310 HINOKITIOL 1 7.05
CHEMBL3978212 1 5.82
CHEMBL1275969 ALPHA-THUJAPLICIN 1 5.02
CHEMBL199975 1 4.50
CHEMBL426110 1 4.42
CHEMBL201626 1 4.41
CHEMBL287556 KOJIC ACID 1 4.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1275999 GAMMA-THUJAPLICIN IC50 = 70.0 nM 7.16
CHEMBL48310 HINOKITIOL IC50 = 90.0 nM 7.05
CHEMBL3978212 IC50 = 1500.0 nM 5.82
CHEMBL1275969 ALPHA-THUJAPLICIN IC50 = 9530.0 nM 5.02
CHEMBL199975 IC50 = 31700.0 nM 4.50
CHEMBL426110 IC50 = 38400.0 nM 4.42
CHEMBL201626 IC50 = 38700.0 nM 4.41
CHEMBL287556 KOJIC ACID IC50 = 53700.0 nM 4.27